A Standardized Method for Quantification of Developing Lymphedema in Patients Treated for Breast Cancer
Identifieur interne : 005A72 ( Main/Exploration ); précédent : 005A71; suivant : 005A73A Standardized Method for Quantification of Developing Lymphedema in Patients Treated for Breast Cancer
Auteurs : Marek Ancukiewicz ; Tara A. Russell ; Jean Otoole ; Michelle Specht ; Marybeth Singer ; Alexandra Kelada ; Colleen D. Murphy ; Jessica Pogachar ; Valeria Gioioso ; Megha Patel ; Melissa Skolny ; Barbara L. Smith ; Alphonse G. TaghianSource :
- International journal of radiation oncology, biology, physics [ 0360-3016 ] ; 2010.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Femelle, Humains, Latéralité fonctionnelle, Lymphoedème (diagnostic), Lymphoedème (étiologie), Membre supérieur (anatomie et histologie), Membre supérieur (anatomopathologie), Normes de référence, Rayons infrarouges, Reproductibilité des résultats, Taille d'organe, Tumeurs du sein ().
- MESH :
- anatomie et histologie : Membre supérieur.
- anatomopathologie : Membre supérieur.
- diagnostic : Lymphoedème.
- étiologie : Lymphoedème.
- Adulte d'âge moyen, Femelle, Humains, Latéralité fonctionnelle, Normes de référence, Rayons infrarouges, Reproductibilité des résultats, Taille d'organe, Tumeurs du sein.
English descriptors
- KwdEn :
- MESH :
- anatomy & histology : Upper Extremity.
- diagnosis : Lymphedema.
- etiology : Lymphedema.
- pathology : Upper Extremity.
- therapy : Breast Neoplasms.
- Female, Functional Laterality, Humans, Infrared Rays, Middle Aged, Organ Size, Reference Standards, Reproducibility of Results.
Abstract
The lack of standard method to quantify developing breast cancer related lymphedema (BCRL) impedes the progress in research and clinical practice. We therefore developed a simple and practical formula for quantifying both the asymmetry of upper extremities' volumes and their temporal changes.
We present the analysis of bilateral perometer measurements of the upper extremity in a series of 677 women who prospectively underwent lymphedema screening during their treatment for unilateral breast cancer at Massachusetts General Hospital between August 2005 and November 2008. Four sources of variation are analyzed: between repeated measurements on the same arm at the same session, between both arms at the baseline (pre-operative) visit, in follow-up measurements, and between patients. We analyze the effects of hand dominance, time since diagnosis and surgery, age, weight, and body mass index (BMI).
The statistical distribution of variation of measurements suggests that the ratio of volume ratios is most appropriate for quantification of both asymmetry and temporal changes. Therefore, we present the formula for Relative Volume Change (RVC): RVC=(A2U1)/(U2A1)-1, where A1, A2 are arm volumes on the side of the treated breast at two different time points, and U1, U2 are volumes on the contralateral side. RVC is not significantly associated with hand dominance, age, or time since diagnosis. Baseline weight correlates (P=0.0016) with higher RVC; however, baseline BMI or weight changes over time do not.
We propose the use of RVC formula to assess the presence and the course of BCRL in clinical practice and research.
Url:
DOI: 10.1016/j.ijrobp.2010.01.001
PubMed: 20605339
PubMed Central: 2952286
Affiliations:
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Russell</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Otoole, Jean" sort="Otoole, Jean" uniqKey="Otoole J" first="Jean" last="Otoole">Jean Otoole</name><affiliation><nlm:aff id="A3">Department of Physical and Occupational Therapy, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Specht, Michelle" sort="Specht, Michelle" uniqKey="Specht M" first="Michelle" last="Specht">Michelle Specht</name><affiliation><nlm:aff id="A4">Division of Surgical Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Singer, Marybeth" sort="Singer, Marybeth" uniqKey="Singer M" first="Marybeth" last="Singer">Marybeth Singer</name><affiliation><nlm:aff id="A5">Division of Medical Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Kelada, Alexandra" sort="Kelada, Alexandra" uniqKey="Kelada A" first="Alexandra" last="Kelada">Alexandra Kelada</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Murphy, Colleen D" sort="Murphy, Colleen D" uniqKey="Murphy C" first="Colleen D." last="Murphy">Colleen D. Murphy</name><affiliation><nlm:aff id="A2">Current Address: Division of Surgical Oncology, Brigham and Women’s Hospital</nlm:aff><wicri:noCountry code="subfield">Brigham and Women’s Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Pogachar, Jessica" sort="Pogachar, Jessica" uniqKey="Pogachar J" first="Jessica" last="Pogachar">Jessica Pogachar</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Gioioso, Valeria" sort="Gioioso, Valeria" uniqKey="Gioioso V" first="Valeria" last="Gioioso">Valeria Gioioso</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Patel, Megha" sort="Patel, Megha" uniqKey="Patel M" first="Megha" last="Patel">Megha Patel</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Skolny, Melissa" sort="Skolny, Melissa" uniqKey="Skolny M" first="Melissa" last="Skolny">Melissa Skolny</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Smith, Barbara L" sort="Smith, Barbara L" uniqKey="Smith B" first="Barbara L" last="Smith">Barbara L. Smith</name><affiliation><nlm:aff id="A4">Division of Surgical Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Taghian, Alphonse G" sort="Taghian, Alphonse G" uniqKey="Taghian A" first="Alphonse G" last="Taghian">Alphonse G. Taghian</name><affiliation><nlm:aff id="A1">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author></analytic><series><title level="j">International journal of radiation oncology, biology, physics</title><idno type="ISSN">0360-3016</idno><idno type="eISSN">1879-355X</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (therapy)</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Infrared Rays</term><term>Lymphedema (diagnosis)</term><term>Lymphedema (etiology)</term><term>Middle Aged</term><term>Organ Size</term><term>Reference Standards</term><term>Reproducibility of Results</term><term>Upper Extremity (anatomy & histology)</term><term>Upper Extremity (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Latéralité fonctionnelle</term><term>Lymphoedème (diagnostic)</term><term>Lymphoedème (étiologie)</term><term>Membre supérieur (anatomie et histologie)</term><term>Membre supérieur (anatomopathologie)</term><term>Normes de référence</term><term>Rayons infrarouges</term><term>Reproductibilité des résultats</term><term>Taille d'organe</term><term>Tumeurs du sein ()</term></keywords><keywords scheme="MESH" qualifier="anatomie et histologie" xml:lang="fr"><term>Membre supérieur</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Membre supérieur</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Upper Extremity</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Upper Extremity</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Infrared Rays</term><term>Middle Aged</term><term>Organ Size</term><term>Reference Standards</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Latéralité fonctionnelle</term><term>Normes de référence</term><term>Rayons infrarouges</term><term>Reproductibilité des résultats</term><term>Taille d'organe</term><term>Tumeurs du sein</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">The lack of standard method to quantify developing breast cancer related lymphedema (BCRL) impedes the progress in research and clinical practice. We therefore developed a simple and practical formula for quantifying both the asymmetry of upper extremities' volumes and their temporal changes.</p></sec><sec sec-type="materials|methods" id="S2"><title>Methods & Materials</title><p id="P2">We present the analysis of bilateral perometer measurements of the upper extremity in a series of 677 women who prospectively underwent lymphedema screening during their treatment for unilateral breast cancer at Massachusetts General Hospital between August 2005 and November 2008. Four sources of variation are analyzed: between repeated measurements on the same arm at the same session, between both arms at the baseline (pre-operative) visit, in follow-up measurements, and between patients. We analyze the effects of hand dominance, time since diagnosis and surgery, age, weight, and body mass index (BMI).</p></sec><sec id="S3"><title>Results</title><p id="P3">The statistical distribution of variation of measurements suggests that the ratio of volume ratios is most appropriate for quantification of both asymmetry and temporal changes. Therefore, we present the formula for Relative Volume Change (RVC): RVC=(A<sub>2</sub>U<sub>1</sub>)/(U<sub>2</sub>A<sub>1</sub>)-1, where A<sub>1</sub>, A<sub>2</sub> are arm volumes on the side of the treated breast at two different time points, and U<sub>1</sub>, U<sub>2</sub> are volumes on the contralateral side. RVC is not significantly associated with hand dominance, age, or time since diagnosis. Baseline weight correlates (P=0.0016) with higher RVC; however, baseline BMI or weight changes over time do not.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">We propose the use of RVC formula to assess the presence and the course of BCRL in clinical practice and research.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ancukiewicz, Marek" sort="Ancukiewicz, Marek" uniqKey="Ancukiewicz M" first="Marek" last="Ancukiewicz">Marek Ancukiewicz</name><name sortKey="Gioioso, Valeria" sort="Gioioso, Valeria" uniqKey="Gioioso V" first="Valeria" last="Gioioso">Valeria Gioioso</name><name sortKey="Kelada, Alexandra" sort="Kelada, Alexandra" uniqKey="Kelada A" first="Alexandra" last="Kelada">Alexandra Kelada</name><name sortKey="Murphy, Colleen D" sort="Murphy, Colleen D" uniqKey="Murphy C" first="Colleen D." last="Murphy">Colleen D. Murphy</name><name sortKey="Otoole, Jean" sort="Otoole, Jean" uniqKey="Otoole J" first="Jean" last="Otoole">Jean Otoole</name><name sortKey="Patel, Megha" sort="Patel, Megha" uniqKey="Patel M" first="Megha" last="Patel">Megha Patel</name><name sortKey="Pogachar, Jessica" sort="Pogachar, Jessica" uniqKey="Pogachar J" first="Jessica" last="Pogachar">Jessica Pogachar</name><name sortKey="Russell, Tara A" sort="Russell, Tara A" uniqKey="Russell T" first="Tara A" last="Russell">Tara A. Russell</name><name sortKey="Singer, Marybeth" sort="Singer, Marybeth" uniqKey="Singer M" first="Marybeth" last="Singer">Marybeth Singer</name><name sortKey="Skolny, Melissa" sort="Skolny, Melissa" uniqKey="Skolny M" first="Melissa" last="Skolny">Melissa Skolny</name><name sortKey="Smith, Barbara L" sort="Smith, Barbara L" uniqKey="Smith B" first="Barbara L" last="Smith">Barbara L. Smith</name><name sortKey="Specht, Michelle" sort="Specht, Michelle" uniqKey="Specht M" first="Michelle" last="Specht">Michelle Specht</name><name sortKey="Taghian, Alphonse G" sort="Taghian, Alphonse G" uniqKey="Taghian A" first="Alphonse G" last="Taghian">Alphonse G. Taghian</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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